295358

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3115150..3115718 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag MR179_RS14485 Protein ID WP_003405865.1
Coordinates 3115150..3115524 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag MR179_RS14490 Protein ID WP_003405863.1
Coordinates 3115521..3115718 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS14450 3111500..3112270 + 771 Protein_2858 adenylate/guanylate cyclase domain-containing protein -
MR179_RS14455 3112222..3112431 - 210 WP_003911400.1 hypothetical protein -
MR179_RS14460 3112465..3113163 + 699 WP_031646953.1 hypothetical protein -
MR179_RS14465 3113178..3113501 - 324 WP_003405871.1 putative quinol monooxygenase -
MR179_RS14470 3113744..3114019 + 276 WP_003405867.1 hypothetical protein -
MR179_RS14475 3113946..3114131 - 186 WP_003901093.1 hypothetical protein -
MR179_RS14480 3114249..3114947 - 699 WP_003898733.1 hypothetical protein -
MR179_RS14485 3115150..3115524 - 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS14490 3115521..3115718 - 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR179_RS14495 3115806..3116879 - 1074 WP_003898732.1 redox-regulated ATPase YchF -
MR179_RS14500 3116942..3117925 + 984 WP_003898731.1 hypothetical protein -
MR179_RS14505 3117942..3118949 - 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MR179_RS14510 3119039..3119677 + 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T295358 WP_003405865.1 NZ_OW052571:c3115524-3115150 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT295358 WP_003405863.1 NZ_OW052571:c3115718-3115521 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TH08

Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References