Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2970388..2971076 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag MR179_RS13825 Protein ID WP_003406304.1
Coordinates 2970388..2970819 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag MR179_RS13830 Protein ID WP_003406302.1
Coordinates 2970816..2971076 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS13800 2966110..2966379 + 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR179_RS13805 2966376..2966669 + 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
MR179_RS13810 2966726..2967556 + 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MR179_RS13815 2967637..2968497 - 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
MR179_RS13820 2968677..2970365 + 1689 WP_003910308.1 PE family protein -
MR179_RS13825 2970388..2970819 - 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS13830 2970816..2971076 - 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
MR179_RS13835 2971152..2972141 - 990 WP_003406301.1 malate dehydrogenase -
MR179_RS13840 2972312..2973412 + 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
MR179_RS13845 2973489..2974670 - 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
MR179_RS13850 2974675..2975499 - 825 WP_003900298.1 trehalose ABC transporter permease SugB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T295357 WP_003406304.1 NZ_OW052571:c2970819-2970388 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT295357 WP_003406302.1 NZ_OW052571:c2971076-2970816 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References