295356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2966110..2966669 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag MR179_RS13805 Protein ID WP_003898789.1
Coordinates 2966376..2966669 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag MR179_RS13800 Protein ID WP_003406322.1
Coordinates 2966110..2966379 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS13790 2961372..2962160 + 789 WP_003406325.1 hypothetical protein -
MR179_RS13795 2962302..2965997 + 3696 WP_003898790.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
MR179_RS13800 2966110..2966379 + 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR179_RS13805 2966376..2966669 + 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MR179_RS13810 2966726..2967556 + 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MR179_RS13815 2967637..2968497 - 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
MR179_RS13820 2968677..2970365 + 1689 WP_003910308.1 PE family protein -
MR179_RS13825 2970388..2970819 - 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS13830 2970816..2971076 - 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T295356 WP_003898789.1 NZ_OW052571:2966376-2966669 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT295356 WP_003406322.1 NZ_OW052571:2966110-2966379 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References