295354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2783692..2784347 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag MR179_RS13005 Protein ID WP_003898861.1
Coordinates 2783946..2784347 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MR179_RS13000 Protein ID WP_003407272.1
Coordinates 2783692..2783949 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS12980 2778879..2780846 - 1968 WP_003407285.1 primosomal protein N' -
MR179_RS12985 2780927..2781664 - 738 WP_031647000.1 lysoplasmalogenase -
MR179_RS12990 2781663..2782625 + 963 WP_003407279.1 alpha/beta hydrolase -
MR179_RS12995 2782650..2783609 + 960 WP_003407276.1 alpha/beta hydrolase -
MR179_RS13000 2783692..2783949 + 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
MR179_RS13005 2783946..2784347 + 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS13010 2784602..2786332 + 1731 WP_010886114.1 PE family protein -
MR179_RS13015 2786378..2787412 - 1035 WP_003407264.1 AraC family transcriptional regulator -
MR179_RS13020 2787490..2788875 + 1386 WP_003911514.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T295354 WP_003898861.1 NZ_OW052571:2783946-2784347 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT295354 WP_003407272.1 NZ_OW052571:2783692-2783949 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References