295353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2671223..2671839 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MR179_RS12505 Protein ID WP_003407593.1
Coordinates 2671223..2671540 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MR179_RS12510 Protein ID WP_003900349.1
Coordinates 2671537..2671839 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS12475 2666232..2667260 - 1029 WP_003407612.1 glycosyltransferase family 2 protein -
MR179_RS12480 2667305..2667703 - 399 WP_003900351.1 hypothetical protein -
MR179_RS12485 2667764..2667976 + 213 WP_003898900.1 dodecin family protein -
MR179_RS12490 2668190..2668807 + 618 WP_009936446.1 class I SAM-dependent methyltransferase -
MR179_RS12495 2668880..2670169 - 1290 WP_003407599.1 serine hydrolase domain-containing protein -
MR179_RS12500 2670222..2671226 - 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MR179_RS12505 2671223..2671540 - 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MR179_RS12510 2671537..2671839 - 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MR179_RS12515 2671853..2674105 - 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MR179_RS12520 2674106..2675953 - 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T295353 WP_003407593.1 NZ_OW052571:c2671540-2671223 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT295353 WP_003900349.1 NZ_OW052571:c2671839-2671537 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References