295352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2592726..2593339 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag MR179_RS12160 Protein ID WP_003407786.1
Coordinates 2592726..2593130 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag MR179_RS12165 Protein ID WP_009935474.1
Coordinates 2593136..2593339 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS12150 2588677..2590974 + 2298 WP_003407790.1 malto-oligosyltrehalose synthase -
MR179_RS12155 2590967..2592709 + 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
MR179_RS12160 2592726..2593130 - 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
MR179_RS12165 2593136..2593339 - 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR179_RS12170 2593392..2594681 - 1290 WP_003407781.1 threonine ammonia-lyase -
MR179_RS12175 2594716..2595162 - 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
MR179_RS12180 2595172..2596320 - 1149 Protein_2410 MMPL family transporter -
MR179_RS12185 2596504..2597112 - 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
MR179_RS12190 2597180..2597557 - 378 WP_003407771.1 fumarate reductase subunit FrdD -
MR179_RS12195 2597554..2597934 - 381 WP_003407768.1 fumarate reductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T295352 WP_003407786.1 NZ_OW052571:c2593130-2592726 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT295352 WP_009935474.1 NZ_OW052571:c2593339-2593136 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References