Detailed information of TA system TA029535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5559157..5559776
• Accession: NC_021499
• Organism: Pseudomonas resinovorans NBRC 106553

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S6B0J5
• Locus tag: PCA10_RS25015
• Protein ID: WP_016494879.1
• Coordinates: 5559594..5559776 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PCA10_RS25010
• Protein ID: WP_041770442.1
• Coordinates: 5559157..5559564 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCA10_RS24990	5555909..5556745	+	837	WP_016494874.1	arylamine N-acetyltransferase	-
PCA10_RS24995	5556857..5557612	+	756	WP_041770441.1	phytanoyl-CoA dioxygenase family protein	-
PCA10_RS25000	5558116..5558568	+	453	WP_016494876.1	LEA type 2 family protein	-
PCA10_RS25005	5558701..5559042	+	342	WP_016494877.1	alkylphosphonate utilization protein	-
PCA10_RS25010	5559157..5559564	-	408	WP_041770442.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PCA10_RS25015	5559594..5559776	-	183	WP_016494879.1	type II toxin-antitoxin system HicA family toxin	Toxin
PCA10_RS25020	5559910..5560704	+	795	WP_016494880.1	NYN domain-containing protein	-
PCA10_RS25025	5561083..5561532	+	450	WP_016494881.1	Bro-N domain-containing protein	-
PCA10_RS25030	5561642..5562175	+	534	WP_016494882.1	transposase	-
PCA10_RS25035	5562312..5562716	+	405	WP_016494883.1	hypothetical protein	-
PCA10_RS25040	5562777..5564273	-	1497	WP_016494884.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
PCA10_RS25045	5564381..5564668	-	288	WP_016494885.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6757.96 Da
• Isoelectric Point: 11.3688

>T29535 WP_016494879.1 NC_021499:c5559776-5559594 [Pseudomonas resinovorans NBRC 106553]
VNSRQLMELIEADGWFLVRVRGSHHHFKHPSKPGLVTIPHPKKDLLPRTAASILKQAGLK

Nucleotide

• Length: 183 bp

>T29535 NC_021499:c5559776-5559594 [Pseudomonas resinovorans NBRC 106553]
GTGAACAGTCGACAACTCATGGAGCTGATCGAGGCCGATGGATGGTTTCTGGTCAGGGTCAGGGGCAGTCATCACCACTT
CAAGCACCCGAGCAAGCCGGGCCTGGTGACGATTCCCCATCCGAAGAAAGACCTGCTGCCCAGGACGGCGGCCAGCATCC
TCAAACAGGCAGGGCTCAAATGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14721.75 Da
• Isoelectric Point: 4.4268

>AT29535 WP_041770442.1 NC_021499:c5559564-5559157 [Pseudomonas resinovorans NBRC 106553]
MLYPIAILPGDDGHAWGVEVPDLPGCFSAGDDLDDAMAMAREAIEGHLELLAEEGAPIPVARKVTFHAANPEYTGCTWAL
VEIDVTRYMGKAEKLNITLPGYLLNRIDEYVRSHPEQKSRSGFLAAAALRVLQES

Nucleotide

• Length: 408 bp

>AT29535 NC_021499:c5559564-5559157 [Pseudomonas resinovorans NBRC 106553]
ATGCTCTACCCGATAGCGATTCTCCCCGGCGACGATGGGCATGCCTGGGGCGTGGAGGTGCCAGACTTGCCGGGCTGCTT
CTCGGCCGGAGATGATCTGGACGATGCGATGGCCATGGCGCGCGAGGCCATCGAGGGGCATCTGGAGTTGCTGGCGGAGG
AGGGTGCGCCGATTCCGGTGGCGAGGAAGGTGACCTTCCATGCGGCGAATCCCGAATACACCGGCTGCACCTGGGCCCTG
GTGGAGATCGACGTGACCCGCTACATGGGCAAGGCGGAGAAGCTGAACATCACCCTGCCGGGCTACCTGCTCAATCGCAT
CGATGAGTACGTGCGCAGCCACCCGGAGCAGAAGAGCCGTTCGGGCTTCCTGGCCGCGGCGGCGTTGCGGGTGTTGCAGG
AGTCTTGA

Structures

Toxin

• AlphaFold DB: S6B0J5