295349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2169914..2170617 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag MR179_RS10260 Protein ID WP_003409778.1
Coordinates 2170288..2170617 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag MR179_RS10255 Protein ID WP_003409780.1
Coordinates 2169914..2170291 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS10215 2165072..2165263 + 192 WP_003409876.1 hypothetical protein -
MR179_RS10220 2165284..2166186 + 903 WP_031657727.1 hypothetical protein -
MR179_RS10225 2166197..2166547 + 351 WP_003899096.1 hypothetical protein -
MR179_RS10230 2166661..2166843 + 183 WP_003409870.1 hypothetical protein -
MR179_RS10235 2166836..2167237 - 402 WP_003409869.1 hypothetical protein -
MR179_RS10240 2167301..2167753 + 453 WP_003899095.1 lipoprotein -
MR179_RS10245 2167908..2169272 - 1365 WP_003903691.1 HNH endonuclease signature motif containing protein -
MR179_RS10250 2169327..2169917 + 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
MR179_RS10255 2169914..2170291 + 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
MR179_RS10260 2170288..2170617 + 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MR179_RS10265 2170827..2171597 - 771 WP_003409775.1 SDR family oxidoreductase -
MR179_RS10270 2171594..2172655 - 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MR179_RS10275 2172652..2173167 - 516 WP_003409718.1 flavin reductase family protein -
MR179_RS10280 2173164..2174234 - 1071 WP_003899091.1 epoxide hydrolase EphB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T295349 WP_003409778.1 NZ_OW052571:2170288-2170617 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT295349 WP_003409780.1 NZ_OW052571:2169914-2170291 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References