295346

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2139159..2139847 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MR179_RS10050 Protein ID WP_003409958.1
Coordinates 2139428..2139847 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MR179_RS10045 Protein ID WP_003409968.1
Coordinates 2139159..2139419 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS10020 2134650..2135249 - 600 WP_003409989.1 L-lysine exporter -
MR179_RS10025 2135358..2136269 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MR179_RS10030 2136354..2136584 - 231 WP_003409980.1 DUF167 domain-containing protein -
MR179_RS10035 2136699..2137352 + 654 WP_003409976.1 cutinase Cfp21 -
MR179_RS10040 2137340..2139016 - 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
MR179_RS10045 2139159..2139419 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR179_RS10050 2139428..2139847 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS10055 2140072..2141040 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MR179_RS10060 2141231..2141917 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
MR179_RS10065 2142096..2143541 + 1446 WP_003899115.1 APC family permease -
MR179_RS10070 2143504..2144352 - 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T295346 WP_003409958.1 NZ_OW052571:2139428-2139847 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT295346 WP_003409968.1 NZ_OW052571:2139159-2139419 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References