295343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2106589..2107215 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag MR179_RS09880 Protein ID WP_003410075.1
Coordinates 2106589..2106987 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag MR179_RS09885 Protein ID WP_003911750.1
Coordinates 2106988..2107215 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS09850 2102188..2103444 + 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -
MR179_RS09855 2103572..2104162 - 591 WP_003899131.1 IS110 family transposase -
MR179_RS09860 2104116..2104736 - 621 WP_003410086.1 IS110 family transposase -
MR179_RS09865 2104824..2105003 + 180 Protein_1949 hypothetical protein -
MR179_RS09870 2105440..2105874 - 435 WP_003914358.1 DUF1398 domain-containing protein -
MR179_RS09875 2105975..2106406 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
MR179_RS09880 2106589..2106987 - 399 WP_003410075.1 PIN domain nuclease Toxin
MR179_RS09885 2106988..2107215 - 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR179_RS09890 2107474..2108643 + 1170 WP_003899126.1 ATP-binding protein -
MR179_RS09895 2108832..2109176 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T295343 WP_003410075.1 NZ_OW052571:c2106987-2106589 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT295343 WP_003911750.1 NZ_OW052571:c2107215-2106988 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References