Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2043793..2044429 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag MR179_RS09600 Protein ID WP_003410654.1
Coordinates 2043793..2044203 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag MR179_RS09605 Protein ID WP_003410651.1
Coordinates 2044196..2044429 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS09580 2039390..2040613 + 1224 WP_003901321.1 class I SAM-dependent methyltransferase -
MR179_RS09585 2040559..2042085 - 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
MR179_RS09590 2042082..2042708 - 627 WP_003410658.1 precorrin-8X methylmutase -
MR179_RS09595 2042718..2043809 - 1092 WP_003900454.1 precorrin-3B synthase -
MR179_RS09600 2043793..2044203 - 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
MR179_RS09605 2044196..2044429 - 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
MR179_RS09610 2044507..2048091 + 3585 WP_003410648.1 cobaltochelatase subunit CobN -
MR179_RS09615 2048175..2048579 + 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
MR179_RS09620 2048580..2048972 - 393 WP_229303073.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T295341 WP_003410654.1 NZ_OW052571:c2044203-2043793 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT295341 WP_003410651.1 NZ_OW052571:c2044429-2044196 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References