295340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2000479..2001174 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag MR179_RS09400 Protein ID WP_003410811.1
Coordinates 2000740..2001174 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MR179_RS09395 Protein ID WP_003410814.1
Coordinates 2000479..2000733 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS09365 1995827..1996021 + 195 WP_003411026.1 ubiquitin-like protein Pup -
MR179_RS09370 1996018..1996893 + 876 WP_003411023.1 proteasome subunit beta -
MR179_RS09375 1996890..1997636 + 747 WP_003906749.1 proteasome subunit alpha -
MR179_RS09380 1998176..1998907 - 732 WP_003900467.1 PPE family protein -
MR179_RS09385 1998963..1999259 - 297 WP_003410820.1 PE family protein -
MR179_RS09390 2000206..2000463 + 258 WP_003410816.1 hypothetical protein -
MR179_RS09395 2000479..2000733 + 255 WP_003410814.1 antitoxin Antitoxin
MR179_RS09400 2000740..2001174 + 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS09405 2001153..2001986 - 834 WP_003899172.1 SWIM zinc finger family protein -
MR179_RS09410 2001979..2005020 - 3042 WP_003899171.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T295340 WP_003410811.1 NZ_OW052571:2000740-2001174 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT295340 WP_003410814.1 NZ_OW052571:2000479-2000733 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References