Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1556479..1557131 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag MR179_RS07275 Protein ID WP_003412752.1
Coordinates 1556479..1556904 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MR179_RS07280 Protein ID WP_003412749.1
Coordinates 1556910..1557131 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS07250 1551484..1552041 + 558 WP_003412768.1 MaoC family dehydratase -
MR179_RS07255 1552038..1552859 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MR179_RS07260 1553118..1554221 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MR179_RS07265 1554232..1555278 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MR179_RS07270 1555275..1556456 + 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
MR179_RS07275 1556479..1556904 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS07280 1556910..1557131 - 222 WP_003412749.1 antitoxin Antitoxin
MR179_RS07285 1557184..1557936 - 753 WP_003900859.1 hypothetical protein -
MR179_RS07290 1557926..1558549 - 624 WP_003900858.1 TIGR00725 family protein -
MR179_RS07295 1558685..1558891 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T295338 WP_003412752.1 NZ_OW052571:c1556904-1556479 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT295338 WP_003412749.1 NZ_OW052571:c1557131-1556910 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References