295337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1510307..1510947 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag MR179_RS07080 Protein ID WP_003412970.1
Coordinates 1510528..1510947 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag MR179_RS07075 Protein ID WP_003412975.1
Coordinates 1510307..1510531 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS07055 1505924..1506487 + 564 WP_003412989.1 elongation factor P -
MR179_RS07060 1506490..1506960 + 471 WP_003899364.1 transcription antitermination factor NusB -
MR179_RS07065 1506960..1507361 + 402 WP_003412981.1 hypothetical protein -
MR179_RS07070 1507433..1510276 + 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
MR179_RS07075 1510307..1510531 + 225 WP_003412975.1 antitoxin VapB39 Antitoxin
MR179_RS07080 1510528..1510947 + 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS07085 1510948..1511898 - 951 WP_003911916.1 ERCC4 domain-containing protein -
MR179_RS07090 1511996..1512202 + 207 WP_229298035.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MR179_RS07095 1512543..1513463 + 921 WP_003412965.1 restriction endonuclease -
MR179_RS07100 1513498..1513899 - 402 WP_003412963.1 PIN domain-containing protein -
MR179_RS07105 1513896..1514123 - 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
MR179_RS07110 1514640..1515362 + 723 WP_003412957.1 DUF1906 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T295337 WP_003412970.1 NZ_OW052571:1510528-1510947 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT295337 WP_003412975.1 NZ_OW052571:1510307-1510531 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References