295333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1434431..1435145 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MR179_RS06710 Protein ID WP_003413460.1
Coordinates 1434431..1434871 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MR179_RS06715 Protein ID WP_030030794.1
Coordinates 1434858..1435145 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS06685 1430343..1431017 - 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -
MR179_RS06690 1431145..1432044 + 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MR179_RS06695 1432073..1432918 + 846 WP_003413466.1 acyl-CoA thioesterase II -
MR179_RS06700 1432926..1433522 + 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MR179_RS06705 1433655..1434410 + 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MR179_RS06710 1434431..1434871 - 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS06715 1434858..1435145 - 288 WP_030030794.1 antitoxin Antitoxin
MR179_RS06720 1435256..1436827 - 1572 WP_003899392.1 polyamine aminopropyltransferase -
MR179_RS06725 1436824..1437282 - 459 WP_003413451.1 DUF350 domain-containing protein -
MR179_RS06730 1437307..1437738 - 432 WP_003899390.1 DUF4247 domain-containing protein -
MR179_RS06735 1437735..1438229 - 495 WP_003413444.1 DUF2617 family protein -
MR179_RS06740 1438240..1438860 - 621 WP_003413441.1 DUF4178 domain-containing protein -
MR179_RS06745 1439077..1439481 - 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS06750 1439478..1439723 - 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T295333 WP_003413460.1 NZ_OW052571:c1434871-1434431 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10512.02 Da        Isoelectric Point: 6.7173

>AT295333 WP_030030794.1 NZ_OW052571:c1435145-1434858 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGDAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure

References