Detailed information of TA system TA029533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2510448..2511076
• Accession: NC_021499
• Organism: Pseudomonas resinovorans NBRC 106553

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S6BG43
• Locus tag: PCA10_RS11315
• Protein ID: WP_016492210.1
• Coordinates: 2510448..2510630 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PCA10_RS11320
• Protein ID: WP_041770650.1
• Coordinates: 2510669..2511076 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCA10_RS11310	2509309..2510271	+	963	WP_016492209.1	alpha/beta hydrolase	-
PCA10_RS11315	2510448..2510630	+	183	WP_016492210.1	type II toxin-antitoxin system HicA family toxin	Toxin
PCA10_RS11320	2510669..2511076	+	408	WP_041770650.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PCA10_RS11325	2511140..2513557	-	2418	WP_041770652.1	TonB-dependent siderophore receptor	-
PCA10_RS11330	2513759..2515054	-	1296	WP_016492213.1	PepSY domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6839.93 Da
• Isoelectric Point: 10.8945

>T29533 WP_016492210.1 NC_021499:2510448-2510630 [Pseudomonas resinovorans NBRC 106553]
MRSRELIKLIEADGWFEVDVKGSHHQFKHPAKKGRVTVPHPKSDLPEGTVRNILKQAGLR

Nucleotide

• Length: 183 bp

>T29533 NC_021499:2510448-2510630 [Pseudomonas resinovorans NBRC 106553]
ATGCGAAGTCGGGAGTTGATCAAGTTGATCGAGGCGGATGGTTGGTTTGAGGTGGATGTCAAAGGCAGTCATCACCAGTT
CAAGCATCCAGCCAAGAAGGGGCGGGTCACCGTGCCTCATCCCAAGAGCGATCTACCGGAGGGTACGGTCCGCAACATTC
TCAAGCAGGCCGGCCTCAGATGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14747.53 Da
• Isoelectric Point: 4.7514

>AT29533 WP_041770650.1 NC_021499:2510669-2511076 [Pseudomonas resinovorans NBRC 106553]
MKFPVVLHKDPGSDYGVTVPDVPGCFSAGETVSEALDNLNEALALHFEGLMADGEAIPQPQEVDVHLANPDYAGGVWAVV
EFDIAPYLGSSVRFNATLPEHLLRRIDERVKSDHRYASRSGFLATAALRELQHPH

Nucleotide

• Length: 408 bp

>AT29533 NC_021499:2510669-2511076 [Pseudomonas resinovorans NBRC 106553]
ATGAAATTTCCAGTCGTATTGCACAAGGACCCAGGCTCCGACTATGGCGTGACGGTTCCGGATGTGCCGGGCTGTTTCTC
CGCGGGCGAGACCGTCAGCGAAGCGCTGGACAACCTCAATGAGGCGCTGGCCCTGCATTTCGAGGGGCTGATGGCGGACG
GTGAAGCCATTCCCCAGCCGCAGGAGGTGGATGTTCACCTGGCCAATCCGGACTACGCCGGTGGTGTCTGGGCTGTCGTG
GAGTTCGATATCGCGCCCTATCTGGGCAGCTCCGTGCGTTTCAATGCGACTCTGCCGGAACACTTGCTGCGACGCATCGA
CGAGCGAGTGAAAAGTGACCATCGCTATGCGTCGCGGTCGGGGTTCCTGGCCACAGCAGCATTGCGGGAGTTGCAGCACC
CGCATTGA

Structures

Toxin

• AlphaFold DB: S6BG43