Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1255677..1256247 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MR179_RS05655 Protein ID WP_003414166.1
Coordinates 1255891..1256247 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MR179_RS05650 Protein ID WP_003901465.1
Coordinates 1255677..1255907 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS05610 1250695..1251006 - 312 WP_003414190.1 hypothetical protein -
MR179_RS05615 1251111..1251368 - 258 WP_003899489.1 hypothetical protein -
MR179_RS05620 1252478..1252738 - 261 Protein_1114 transposase -
MR179_RS05625 1252955..1253146 - 192 WP_003414184.1 hypothetical protein -
MR179_RS05630 1253143..1253547 - 405 WP_009938577.1 hypothetical protein -
MR179_RS05635 1253695..1253949 + 255 WP_003917684.1 hypothetical protein -
MR179_RS05640 1254125..1254592 - 468 WP_003414177.1 DUF1778 domain-containing protein -
MR179_RS05645 1254591..1255634 + 1044 WP_003414172.1 DUF2293 domain-containing protein -
MR179_RS05650 1255677..1255907 + 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
MR179_RS05655 1255891..1256247 + 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MR179_RS05660 1256349..1257998 - 1650 WP_003899485.1 CocE/NonD family hydrolase -
MR179_RS05665 1258017..1258604 - 588 WP_003914429.1 DUF3558 family protein -
MR179_RS05670 1258777..1259103 + 327 WP_003414157.1 hypothetical protein -
MR179_RS05675 1259107..1260795 + 1689 WP_003414155.1 alpha/beta hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T295329 WP_003414166.1 NZ_OW052571:1255891-1256247 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT295329 WP_003901465.1 NZ_OW052571:1255677-1255907 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References