295323

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 661762..662436 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag MR179_RS02930 Protein ID WP_003417282.1
Coordinates 662008..662436 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag MR179_RS02925 Protein ID WP_003417286.1
Coordinates 661762..662004 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS02900 658358..659362 + 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -
MR179_RS02905 659459..659833 + 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
MR179_RS02910 659830..660363 + 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
MR179_RS02915 660364..661029 + 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
MR179_RS02920 661026..661640 + 615 WP_003417288.1 class I SAM-dependent methyltransferase -
MR179_RS02925 661762..662004 + 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
MR179_RS02930 662008..662436 + 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS02935 662515..663306 - 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
MR179_RS02940 663306..665078 - 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
MR179_RS02945 665207..665641 - 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
MR179_RS02950 665638..665976 - 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
MR179_RS02955 666213..666614 + 402 WP_003417264.1 cytidine deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T295323 WP_003417282.1 NZ_OW052571:662008-662436 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT295323 WP_003417286.1 NZ_OW052571:661762-662004 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References