295322

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 592903..593432 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MR179_RS02720 Protein ID WP_003417760.1
Coordinates 592903..593160 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MR179_RS02725 Protein ID WP_003417757.1
Coordinates 593157..593432 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS02690 589331..589723 + 393 WP_003417776.1 serine protease inhibitor -
MR179_RS02695 589701..590069 + 369 WP_003417772.1 DUF742 domain-containing protein -
MR179_RS02700 590050..590631 + 582 WP_003417769.1 ATP/GTP-binding protein -
MR179_RS02705 590638..591189 + 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MR179_RS02710 591186..591554 - 369 WP_003417765.1 FHA domain-containing protein -
MR179_RS02715 591671..592861 - 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MR179_RS02720 592903..593160 - 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MR179_RS02725 593157..593432 - 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MR179_RS02730 593556..594401 + 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MR179_RS02735 594398..594691 + 294 WP_003417749.1 DUF3017 domain-containing protein -
MR179_RS02740 594705..595094 - 390 WP_003417745.1 DUF732 domain-containing protein -
MR179_RS02745 595209..595469 + 261 WP_003417741.1 hypothetical protein -
MR179_RS02750 595496..595983 + 488 Protein_544 FAD-binding protein -
MR179_RS02755 596170..596859 + 690 WP_003917774.1 BBE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T295322 WP_003417760.1 NZ_OW052571:c593160-592903 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT295322 WP_003417757.1 NZ_OW052571:c593432-593157 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References