Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1667923..1669618 Replicon
Accession NC_021499
Organism Pseudomonas resinovorans NBRC 106553

Toxin (Protein)


Gene name doc Uniprot ID S6AGP3
Locus tag PCA10_RS07715 Protein ID WP_016491492.1
Coordinates 1667923..1668792 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID S6AT22
Locus tag PCA10_RS07720 Protein ID WP_016491493.1
Coordinates 1668785..1669618 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCA10_RS07690 1663929..1664780 + 852 WP_081663920.1 ABC transporter ATP-binding protein -
PCA10_RS07695 1664818..1665813 + 996 WP_016491488.1 ABC transporter substrate-binding protein -
PCA10_RS07700 1665823..1666599 + 777 WP_016491489.1 ABC transporter permease -
PCA10_RS07705 1666605..1667366 + 762 WP_016491490.1 SDR family oxidoreductase -
PCA10_RS07710 1667378..1667914 + 537 WP_016491491.1 cupin domain-containing protein -
PCA10_RS07715 1667923..1668792 + 870 WP_016491492.1 alpha/beta hydrolase Toxin
PCA10_RS07720 1668785..1669618 + 834 WP_016491493.1 IclR family transcriptional regulator Antitoxin
PCA10_RS07725 1669605..1670402 + 798 WP_016491494.1 SDR family oxidoreductase -
PCA10_RS07730 1670395..1672077 + 1683 WP_016491495.1 thiamine pyrophosphate-binding protein -
PCA10_RS07735 1672088..1672891 + 804 WP_016491496.1 aspartate dehydrogenase -
PCA10_RS07740 1672902..1674386 + 1485 WP_016491497.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, C-terminal

(130-253)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30444.83 Da        Isoelectric Point: 7.3626

>T29532 WP_016491492.1 NC_021499:1667923-1668792 [Pseudomonas resinovorans NBRC 106553]
MNMAQTRIPAPSLPQSFPERLVQLADGAQVAIRECGQGPAVVLLHGIGSGSASWLHCAQRLAASCRVIAWDAPGYGQSTP
LPQAQPRAGDYAARLELLLAELGVERCLLVGHSLGALMATAYASGVGAARVGRLLLISPARGYGAPELRDSGLRVRQQRL
DNLERLGIDGLASERTARLLGPNPSEGALAWVRWNMARLNPHGYRQAVELLCGDDLLAYGVPAMPCEVHCGEADGITPPQ
NCSAIARLLDAPFSMIPGAGHASPIEQPEVVAGRIGHAQRHSFQGTANG

Download         Length: 870 bp

>T29532 NC_021499:1667923-1668792 [Pseudomonas resinovorans NBRC 106553]
ATGAACATGGCGCAGACCCGCATCCCCGCCCCCAGCCTGCCGCAGAGCTTCCCCGAGCGCCTGGTGCAACTCGCCGACGG
CGCCCAGGTGGCGATCCGCGAGTGCGGCCAGGGCCCCGCCGTGGTGCTGTTGCACGGCATAGGCTCCGGTTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCGAGCTGCCGGGTGATCGCCTGGGACGCACCCGGCTACGGGCAATCCACACCG
CTGCCGCAGGCGCAGCCCAGGGCCGGTGACTACGCCGCGCGACTGGAGCTGCTGCTGGCGGAACTGGGGGTGGAGCGCTG
CCTGCTGGTCGGGCATTCGCTCGGCGCGCTGATGGCCACGGCCTATGCCAGTGGCGTCGGCGCGGCGCGGGTCGGCCGCC
TGCTGCTGATCAGCCCGGCACGCGGCTACGGCGCGCCGGAACTGCGTGACAGCGGCCTGCGGGTGCGCCAGCAACGCCTG
GACAACCTCGAGCGCCTGGGCATCGACGGCCTGGCCAGCGAGCGCACCGCACGCCTGCTGGGCCCCAACCCCAGCGAGGG
CGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCGCACGGCTACCGCCAGGCCGTCGAGTTGCTCTGCGGCG
ACGACCTGCTGGCCTACGGCGTGCCCGCCATGCCCTGCGAAGTGCACTGCGGCGAAGCCGACGGCATTACCCCGCCGCAG
AACTGCAGCGCCATCGCTCGTTTGCTCGACGCGCCGTTCTCGATGATTCCCGGGGCCGGCCATGCCAGCCCCATCGAACA
ACCCGAAGTGGTAGCAGGACGCATCGGCCACGCACAACGCCACTCTTTCCAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30771.15 Da        Isoelectric Point: 6.6069

>AT29532 WP_016491493.1 NC_021499:1668785-1669618 [Pseudomonas resinovorans NBRC 106553]
MDKPDDPQDKYIVPGLERGLLLLCEFSRKNRTLSAPELARRLKLPRSTIFRLLTTLETMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNQLCDDIRYPCNLVVRDGRSIVYVAKVSPSTLLTSTVNVGTRLPAHATVLGRILLQDLSLGELR
DLYPEEHLESYSPNTPRTVLELFNLLQSDRLRGFVQGEGFFESTISTVAAPVRDHSGKVVAAMGATIPSGHIEPNSIDNL
VSTVRASADQLSHLLNYAPDSHDNVTSIFRSKQHESV

Download         Length: 834 bp

>AT29532 NC_021499:1668785-1669618 [Pseudomonas resinovorans NBRC 106553]
ATGGATAAGCCAGACGATCCGCAAGACAAGTACATAGTGCCCGGCCTGGAGCGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGAACCGTACCCTGTCGGCACCGGAGCTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAAACCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGCTGCGTCTGGGCTTC
GAGTACCTGGCCTCGCTGGAACTGACCGAACTCGGCCAGCCGCTGCTGAACCAGCTGTGCGACGACATCCGCTACCCCTG
CAACCTGGTGGTACGCGATGGCCGCTCCATCGTCTACGTGGCCAAGGTCTCGCCCTCCACCTTGCTGACCAGCACGGTCA
ACGTCGGCACCCGCCTGCCGGCCCACGCCACCGTGCTCGGCCGCATCCTCCTGCAGGACCTGTCGCTGGGCGAGCTGCGC
GACCTGTACCCGGAAGAACACCTGGAAAGCTACTCGCCGAACACCCCGCGTACCGTGCTGGAGCTGTTCAACCTGCTGCA
GAGCGATCGCCTGCGCGGCTTCGTCCAGGGCGAGGGCTTCTTCGAGTCGACCATCTCCACCGTGGCCGCGCCGGTGCGCG
ACCACAGCGGCAAGGTGGTGGCCGCCATGGGCGCCACCATCCCCTCGGGGCACATCGAGCCGAACAGCATCGACAACCTG
GTGAGCACCGTGCGCGCCAGCGCCGACCAGCTGTCGCACCTGCTCAACTACGCCCCGGACAGCCACGACAACGTCACCTC
CATCTTCCGGAGCAAGCAGCATGAGTCTGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S6AGP3

Antitoxin

Source ID Structure
AlphaFold DB S6AT22

References