Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4338600..4339236 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MR177_RS20260 Protein ID WP_003904769.1
Coordinates 4338600..4339010 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag MR177_RS20265 Protein ID WP_003410651.1
Coordinates 4339003..4339236 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS20240 4334197..4335420 + 1224 WP_003901321.1 class I SAM-dependent methyltransferase -
MR177_RS20245 4335366..4336892 - 1527 WP_242302826.1 precorrin-2 C(20)-methyltransferase -
MR177_RS20250 4336889..4337515 - 627 WP_031657419.1 precorrin-8X methylmutase -
MR177_RS20255 4337525..4338616 - 1092 WP_003900454.1 precorrin-3B synthase -
MR177_RS20260 4338600..4339010 - 411 WP_003904769.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
MR177_RS20265 4339003..4339236 - 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
MR177_RS20270 4339314..4342898 + 3585 WP_003410648.1 cobaltochelatase subunit CobN -
MR177_RS20275 4342982..4343386 + 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
MR177_RS20280 4343387..4343779 - 393 WP_229303073.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14176.35 Da        Isoelectric Point: 9.4835

>T295318 WP_003904769.1 NZ_OW052570:c4339010-4338600 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMPAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT295318 WP_003410651.1 NZ_OW052570:c4339236-4339003 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References