295317

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4295271..4295966 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag MR177_RS20065 Protein ID WP_003410811.1
Coordinates 4295532..4295966 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MR177_RS20060 Protein ID WP_003410814.1
Coordinates 4295271..4295525 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS20030 4290619..4290813 + 195 WP_003411026.1 ubiquitin-like protein Pup -
MR177_RS20035 4290810..4291685 + 876 WP_003411023.1 proteasome subunit beta -
MR177_RS20040 4291682..4292428 + 747 WP_003901330.1 proteasome subunit alpha -
MR177_RS20045 4292968..4293699 - 732 WP_003900467.1 PPE family protein -
MR177_RS20050 4293755..4294051 - 297 WP_003410820.1 PE family protein -
MR177_RS20055 4294998..4295255 + 258 WP_003410816.1 hypothetical protein -
MR177_RS20060 4295271..4295525 + 255 WP_003410814.1 antitoxin Antitoxin
MR177_RS20065 4295532..4295966 + 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS20070 4295945..4296778 - 834 WP_003899172.1 SWIM zinc finger family protein -
MR177_RS20075 4296771..4299812 - 3042 WP_003899171.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T295317 WP_003410811.1 NZ_OW052570:4295532-4295966 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT295317 WP_003410814.1 NZ_OW052570:4295271-4295525 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References