295315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3852460..3853112 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag MR177_RS17955 Protein ID WP_003412752.1
Coordinates 3852460..3852885 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MR177_RS17960 Protein ID WP_003412749.1
Coordinates 3852891..3853112 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS17930 3847465..3848022 + 558 WP_003412768.1 MaoC family dehydratase -
MR177_RS17935 3848019..3848840 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MR177_RS17940 3849099..3850202 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MR177_RS17945 3850213..3851259 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MR177_RS17950 3851256..3852437 + 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
MR177_RS17955 3852460..3852885 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS17960 3852891..3853112 - 222 WP_003412749.1 antitoxin Antitoxin
MR177_RS17965 3853165..3853917 - 753 WP_003901416.1 hypothetical protein -
MR177_RS17970 3853907..3854530 - 624 WP_003900858.1 TIGR00725 family protein -
MR177_RS17975 3854666..3854872 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T295315 WP_003412752.1 NZ_OW052570:c3852885-3852460 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT295315 WP_003412749.1 NZ_OW052570:c3853112-3852891 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References