295311

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3790175..3790812 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag MR177_RS17650 Protein ID WP_003413180.1
Coordinates 3790417..3790812 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag MR177_RS17645 Protein ID WP_003413183.1
Coordinates 3790175..3790420 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS17625 3786769..3787281 + 513 WP_003413197.1 Holliday junction resolvase RuvX -
MR177_RS17630 3787274..3788527 + 1254 WP_003413196.1 endolytic transglycosylase MltG -
MR177_RS17635 3788524..3789333 + 810 WP_003413193.1 shikimate dehydrogenase -
MR177_RS17640 3789345..3789764 + 420 WP_003413190.1 A24 family peptidase -
MR177_RS17645 3790175..3790420 + 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
MR177_RS17650 3790417..3790812 + 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
MR177_RS17655 3790912..3791286 + 375 WP_003413177.1 hypothetical protein -
MR177_RS17660 3791302..3791679 - 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
MR177_RS17665 3791676..3791933 - 258 WP_003413167.1 CopG family transcriptional regulator -
MR177_RS17670 3791972..3792385 - 414 WP_003413164.1 PIN domain nuclease -
MR177_RS17675 3792478..3792756 - 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
MR177_RS17680 3792753..3793415 - 663 WP_003900848.1 LppA family lipoprotein -
MR177_RS17685 3793412..3794071 - 660 WP_003900847.1 LppA family lipoprotein -
MR177_RS17690 3794068..3794727 - 660 WP_003900846.1 LppA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T295311 WP_003413180.1 NZ_OW052570:3790417-3790812 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT295311 WP_003413183.1 NZ_OW052570:3790175-3790420 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References