295307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3560815..3561385 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MR177_RS16400 Protein ID WP_003414166.1
Coordinates 3561029..3561385 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MR177_RS16395 Protein ID WP_003901465.1
Coordinates 3560815..3561045 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS16355 3555833..3556144 - 312 WP_003414190.1 hypothetical protein -
MR177_RS16360 3556249..3556506 - 258 WP_003899489.1 hypothetical protein -
MR177_RS16365 3557616..3557876 - 261 Protein_3234 transposase -
MR177_RS16370 3558093..3558284 - 192 WP_003414184.1 hypothetical protein -
MR177_RS16375 3558281..3558685 - 405 WP_003414181.1 hypothetical protein -
MR177_RS16380 3558833..3559087 + 255 WP_003917684.1 hypothetical protein -
MR177_RS16385 3559263..3559730 - 468 WP_003414177.1 DUF1778 domain-containing protein -
MR177_RS16390 3559729..3560772 + 1044 WP_003414172.1 DUF2293 domain-containing protein -
MR177_RS16395 3560815..3561045 + 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
MR177_RS16400 3561029..3561385 + 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MR177_RS16405 3561487..3563136 - 1650 WP_003899485.1 CocE/NonD family hydrolase -
MR177_RS16410 3563155..3563742 - 588 WP_003914429.1 DUF3558 family protein -
MR177_RS16415 3563915..3564241 + 327 WP_003414157.1 hypothetical protein -
MR177_RS16420 3564245..3565933 + 1689 WP_242302795.1 alpha/beta hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T295307 WP_003414166.1 NZ_OW052570:3561029-3561385 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT295307 WP_003901465.1 NZ_OW052570:3560815-3561045 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References