Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3534705..3536479 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag MR177_RS16275 Protein ID WP_003414409.1
Coordinates 3535595..3536479 (+) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag MR177_RS16270 Protein ID WP_003414414.1
Coordinates 3534705..3535592 (+) Length 296 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS16240 3531007..3532089 + 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
MR177_RS16245 3532168..3532917 - 750 WP_003414497.1 enoyl-CoA hydratase -
MR177_RS16250 3532964..3533179 + 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR177_RS16255 3533176..3533568 + 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
MR177_RS16260 3533589..3533858 + 270 WP_003912856.1 DUF2277 family protein -
MR177_RS16265 3533855..3534400 + 546 WP_242302794.1 DUF1802 family protein -
MR177_RS16270 3534705..3535592 + 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
MR177_RS16275 3535595..3536479 + 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MR177_RS16280 3536751..3537296 + 546 WP_003904931.1 DUF1802 family protein -
MR177_RS16285 3537630..3538418 + 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
MR177_RS16290 3538415..3540853 + 2439 WP_003900580.1 type III-A CRISPR-associated protein Cas10/Csm1 -
MR177_RS16295 3540850..3541224 + 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T295306 WP_003414409.1 NZ_OW052570:3535595-3536479 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT295306 WP_003414414.1 NZ_OW052570:3534705-3535592 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6Y56

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References