295303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3486363..3487059 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag MR177_RS16030 Protein ID WP_003414624.1
Coordinates 3486363..3486806 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MR177_RS16035 Protein ID WP_193566358.1
Coordinates 3486793..3487059 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS16005 3482211..3482477 - 267 WP_015456449.1 DUF2631 domain-containing protein -
MR177_RS16010 3482577..3483158 - 582 WP_003414644.1 fasciclin domain-containing protein -
MR177_RS16015 3483254..3485002 - 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
MR177_RS16020 3485334..3485525 - 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MR177_RS16025 3485621..3486283 - 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
MR177_RS16030 3486363..3486806 - 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS16035 3486793..3487059 - 267 WP_193566358.1 ribbon-helix-helix domain-containing protein Antitoxin
MR177_RS16040 3487177..3488418 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MR177_RS16045 3488426..3489640 + 1215 WP_003414610.1 zinc metalloprotease Rip -
MR177_RS16050 3489657..3490820 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MR177_RS16055 3490876..3491730 + 855 WP_003899516.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T295303 WP_003414624.1 NZ_OW052570:c3486806-3486363 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9344.66 Da        Isoelectric Point: 10.5414

>AT295303 WP_193566358.1 NZ_OW052570:c3487059-3486793 [Mycobacterium tuberculosis]
MPCVRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMND
GVSVDAVR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure

References