295301

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2961148..2961822 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag MR177_RS13660 Protein ID WP_003417282.1
Coordinates 2961394..2961822 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag MR177_RS13655 Protein ID WP_003417286.1
Coordinates 2961148..2961390 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS13630 2957744..2958748 + 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -
MR177_RS13635 2958845..2959219 + 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
MR177_RS13640 2959216..2959749 + 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
MR177_RS13645 2959750..2960415 + 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
MR177_RS13650 2960412..2961026 + 615 WP_003417288.1 class I SAM-dependent methyltransferase -
MR177_RS13655 2961148..2961390 + 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
MR177_RS13660 2961394..2961822 + 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS13665 2961901..2962692 - 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
MR177_RS13670 2962692..2964464 - 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
MR177_RS13675 2964593..2965027 - 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
MR177_RS13680 2965024..2965362 - 339 WP_003904248.1 succinate dehydrogenase, cytochrome b556 subunit -
MR177_RS13685 2965599..2966000 + 402 WP_003417264.1 cytidine deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T295301 WP_003417282.1 NZ_OW052570:2961394-2961822 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT295301 WP_003417286.1 NZ_OW052570:2961148-2961390 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References