295300

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 2897818..2898347 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MR177_RS13450 Protein ID WP_003417760.1
Coordinates 2897818..2898075 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MR177_RS13455 Protein ID WP_003417757.1
Coordinates 2898072..2898347 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS13420 2894246..2894638 + 393 WP_003417776.1 serine protease inhibitor -
MR177_RS13425 2894616..2894984 + 369 WP_003417772.1 DUF742 domain-containing protein -
MR177_RS13430 2894965..2895546 + 582 WP_003417769.1 ATP/GTP-binding protein -
MR177_RS13435 2895553..2896104 + 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MR177_RS13440 2896101..2896469 - 369 WP_003417765.1 FHA domain-containing protein -
MR177_RS13445 2896586..2897776 - 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MR177_RS13450 2897818..2898075 - 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MR177_RS13455 2898072..2898347 - 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MR177_RS13460 2898471..2899316 + 846 WP_003905054.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MR177_RS13465 2899313..2899606 + 294 WP_003417749.1 DUF3017 domain-containing protein -
MR177_RS13470 2899620..2900009 - 390 WP_003417745.1 DUF732 domain-containing protein -
MR177_RS13475 2900124..2900384 + 261 WP_003417741.1 hypothetical protein -
MR177_RS13480 2900411..2900898 + 488 Protein_2661 FAD-binding protein -
MR177_RS13485 2901085..2901774 + 690 WP_003917774.1 BBE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T295300 WP_003417760.1 NZ_OW052570:c2898075-2897818 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT295300 WP_003417757.1 NZ_OW052570:c2898347-2898072 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References