Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 1808358..1809369 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MR177_RS08585 Protein ID WP_003401859.1
Coordinates 1808776..1809369 (+) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MR177_RS08580 Protein ID WP_003401860.1
Coordinates 1808358..1808747 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS08555 1804206..1804961 + 756 WP_003401865.1 XdhC family protein -
MR177_RS08560 1804958..1805551 + 594 WP_003401864.1 NTP transferase domain-containing protein -
MR177_RS08565 1805548..1806444 + 897 WP_003902972.1 MoxR family ATPase -
MR177_RS08570 1806458..1807060 + 603 WP_003898417.1 SRPBCC family protein -
MR177_RS08575 1807066..1808277 + 1212 WP_003904390.1 VWA domain-containing protein -
MR177_RS08580 1808358..1808747 + 390 WP_003401860.1 hypothetical protein Antitoxin
MR177_RS08585 1808776..1809369 + 594 WP_003401859.1 zeta toxin family protein Toxin
MR177_RS08590 1809394..1810524 + 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MR177_RS08595 1810513..1811196 - 684 WP_242302890.1 VTT domain-containing protein -
MR177_RS08600 1811292..1812326 + 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MR177_RS08605 1812338..1813720 - 1383 WP_003898415.1 magnesium transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T295293 WP_003401859.1 NZ_OW052570:1808776-1809369 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT295293 WP_003401860.1 NZ_OW052570:1808358-1808747 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References