295290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 1557211..1557857 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag MR177_RS07395 Protein ID WP_003403122.1
Coordinates 1557465..1557857 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag MR177_RS07390 Protein ID WP_003403125.1
Coordinates 1557211..1557468 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS07355 1552529..1552840 - 312 WP_003403164.1 hypothetical protein -
MR177_RS07360 1552963..1553658 + 696 WP_200861092.1 two-component system response regulator TcrA -
MR177_RS07365 1553642..1554172 + 531 WP_003917320.1 two component system sensor kinase HK2 -
MR177_RS07370 1554286..1554792 + 507 WP_003900973.1 two component system sensor kinase HK1 -
MR177_RS07375 1554896..1555132 + 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
MR177_RS07380 1555129..1555542 + 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
MR177_RS07385 1555793..1557028 + 1236 WP_003403128.1 ATP-binding protein -
MR177_RS07390 1557211..1557468 + 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
MR177_RS07395 1557465..1557857 + 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
MR177_RS07400 1557909..1559459 - 1551 WP_003403119.1 MlaD family protein -
MR177_RS07405 1559464..1560606 - 1143 WP_003911253.1 virulence factor Mce family protein -
MR177_RS07410 1560669..1562195 - 1527 WP_003403112.1 virulence factor Mce family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T295290 WP_003403122.1 NZ_OW052570:1557465-1557857 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT295290 WP_003403125.1 NZ_OW052570:1557211-1557468 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References