295288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1548809..1549452 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag MR177_RS07325 Protein ID WP_003403187.1
Coordinates 1548809..1549210 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag MR177_RS07330 Protein ID WP_003403184.1
Coordinates 1549207..1549452 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS07300 1545767..1546372 - 606 WP_003898526.1 hypothetical protein -
MR177_RS07305 1546514..1546735 + 222 WP_003898525.1 DUF4926 domain-containing protein -
MR177_RS07310 1546787..1547944 + 1158 Protein_1440 hypothetical protein -
MR177_RS07315 1548024..1548221 + 198 WP_003403191.1 hypothetical protein -
MR177_RS07320 1548639..1548818 - 180 Protein_1442 hypothetical protein -
MR177_RS07325 1548809..1549210 - 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS07330 1549207..1549452 - 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR177_RS07335 1549497..1549967 - 471 WP_003898523.1 hypothetical protein -
MR177_RS07340 1549970..1550680 - 711 Protein_1446 IS607 family element RNA-guided endonuclease TnpB -
MR177_RS07345 1550682..1551266 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
MR177_RS07350 1551507..1552457 - 951 WP_003907436.1 DUF1259 domain-containing protein -
MR177_RS07355 1552529..1552840 - 312 WP_003403164.1 hypothetical protein -
MR177_RS07360 1552963..1553658 + 696 WP_200861092.1 two-component system response regulator TcrA -
MR177_RS07365 1553642..1554172 + 531 WP_003917320.1 two component system sensor kinase HK2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T295288 WP_003403187.1 NZ_OW052570:c1549210-1548809 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT295288 WP_003403184.1 NZ_OW052570:c1549452-1549207 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References