295287

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1541289..1541914 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MR177_RS07275 Protein ID WP_003403218.1
Coordinates 1541289..1541690 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MR177_RS07280 Protein ID WP_003403213.1
Coordinates 1541687..1541914 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS07250 1536378..1537325 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR177_RS07255 1537336..1538493 - 1158 WP_003903091.1 hypothetical protein -
MR177_RS07260 1538888..1539979 - 1092 WP_003900977.1 galactokinase -
MR177_RS07265 1539976..1541058 - 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
MR177_RS07270 1541077..1541160 - 84 Protein_1432 galactose-1-phosphate uridylyltransferase -
MR177_RS07275 1541289..1541690 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MR177_RS07280 1541687..1541914 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MR177_RS07285 1542109..1542351 - 243 WP_003403210.1 hypothetical protein -
MR177_RS07290 1542348..1543097 - 750 WP_003898528.1 hypothetical protein -
MR177_RS07295 1543181..1545748 + 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
MR177_RS07300 1545767..1546372 - 606 WP_003898526.1 hypothetical protein -
MR177_RS07305 1546514..1546735 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T295287 WP_003403218.1 NZ_OW052570:c1541690-1541289 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT295287 WP_003403213.1 NZ_OW052570:c1541914-1541687 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References