295286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1535636..1536285 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag MR177_RS07240 Protein ID WP_003403236.1
Coordinates 1535636..1536031 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag MR177_RS07245 Protein ID WP_003403235.1
Coordinates 1536031..1536285 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS07215 1530963..1532690 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
MR177_RS07220 1532783..1533934 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MR177_RS07225 1534006..1534413 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
MR177_RS07230 1534410..1534670 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR177_RS07235 1534802..1535542 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
MR177_RS07240 1535636..1536031 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
MR177_RS07245 1536031..1536285 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
MR177_RS07250 1536378..1537325 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR177_RS07255 1537336..1538493 - 1158 WP_003903091.1 hypothetical protein -
MR177_RS07260 1538888..1539979 - 1092 WP_003900977.1 galactokinase -
MR177_RS07265 1539976..1541058 - 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
MR177_RS07270 1541077..1541160 - 84 Protein_1432 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T295286 WP_003403236.1 NZ_OW052570:c1536031-1535636 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT295286 WP_003403235.1 NZ_OW052570:c1536285-1536031 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References