295281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1496139..1496827 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag MR177_RS07030 Protein ID WP_003403386.1
Coordinates 1496390..1496827 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag MR177_RS07025 Protein ID WP_003911263.1
Coordinates 1496139..1496393 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS07005 1492853..1493026 - 174 WP_003898549.1 hypothetical protein -
MR177_RS07010 1493023..1493361 - 339 WP_003403405.1 PIN domain-containing protein -
MR177_RS07015 1493273..1493599 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR177_RS07020 1493662..1496025 - 2364 WP_031657581.1 arylsulfatase AtsD -
MR177_RS07025 1496139..1496393 + 255 WP_003911263.1 antitoxin VapB7 Antitoxin
MR177_RS07030 1496390..1496827 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS07035 1496937..1497182 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
MR177_RS07040 1497169..1497477 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MR177_RS07045 1497753..1498469 + 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
MR177_RS07050 1498545..1498700 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
MR177_RS07055 1498795..1499178 + 384 WP_003403365.1 ribonuclease VapC6 -
MR177_RS07060 1499566..1500576 - 1011 WP_031653722.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T295281 WP_003403386.1 NZ_OW052570:1496390-1496827 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT295281 WP_003911263.1 NZ_OW052570:1496139-1496393 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References