Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1237686..1238305 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MR177_RS05720 Protein ID WP_003404726.1
Coordinates 1237686..1238120 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag MR177_RS05725 Protein ID WP_003404724.1
Coordinates 1238126..1238305 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS05695 1233021..1234259 + 1239 WP_003404744.1 acetyl-CoA acetyltransferase -
MR177_RS05700 1234261..1235769 + 1509 WP_003404742.1 carotenoid oxygenase family protein -
MR177_RS05705 1235936..1236166 + 231 WP_003898642.1 hypothetical protein -
MR177_RS05710 1236301..1236750 - 450 WP_003404738.1 hypothetical protein -
MR177_RS05715 1236815..1237588 - 774 WP_003404735.1 VOC family protein -
MR177_RS05720 1237686..1238120 - 435 WP_003404726.1 SRPBCC family protein Toxin
MR177_RS05725 1238126..1238305 - 180 WP_003404724.1 antitoxin Antitoxin
MR177_RS05730 1238431..1238589 - 159 WP_003404720.1 hypothetical protein -
MR177_RS05735 1238862..1241255 - 2394 WP_003898639.1 cation-translocating P-type ATPase -
MR177_RS05740 1241252..1242832 - 1581 WP_003909313.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T295279 WP_003404726.1 NZ_OW052570:c1238120-1237686 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT295279 WP_003404724.1 NZ_OW052570:c1238305-1238126 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References