295278

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1227802..1228775 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag MR177_RS05665 Protein ID WP_003404756.1
Coordinates 1227802..1228302 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag MR177_RS05670 Protein ID WP_003404754.1
Coordinates 1228299..1228775 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS05645 1223649..1225301 - 1653 Protein_1116 IS607 family element RNA-guided endonuclease TnpB -
MR177_RS05650 1225301..1225882 - 582 WP_003904507.1 IS607-like element IS1535 family transposase -
MR177_RS05655 1226170..1227489 + 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
MR177_RS05665 1227802..1228302 - 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
MR177_RS05670 1228299..1228775 - 477 WP_003404754.1 DUF1778 domain-containing protein Antitoxin
MR177_RS05675 1228864..1229118 - 255 WP_003898646.1 hypothetical protein -
MR177_RS05680 1229118..1230899 - 1782 WP_003903231.1 BCCT family transporter -
MR177_RS05685 1231343..1231642 + 300 WP_003404748.1 PE family protein -
MR177_RS05690 1231657..1232928 + 1272 WP_003404747.1 PPE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T295278 WP_003404756.1 NZ_OW052570:c1228302-1227802 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT295278 WP_003404754.1 NZ_OW052570:c1228775-1228299 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB G0TFR4

References