295276

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1024124..1024755 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag MR177_RS04670 Protein ID WP_003405820.1
Coordinates 1024444..1024755 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MR177_RS04665 Protein ID WP_003405836.1
Coordinates 1024124..1024444 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS04640 1019320..1019958 + 639 WP_003898730.1 lipid droplet-associated protein -
MR177_RS04645 1019955..1021202 + 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MR177_RS04650 1021192..1021449 + 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MR177_RS04655 1021459..1022571 + 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MR177_RS04660 1022578..1024114 - 1537 Protein_922 carboxylesterase/lipase family protein -
MR177_RS04665 1024124..1024444 + 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MR177_RS04670 1024444..1024755 + 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MR177_RS04675 1024867..1026024 + 1158 WP_003898727.1 AI-2E family transporter -
MR177_RS04680 1026031..1026675 - 645 WP_003915494.1 DUF4245 domain-containing protein -
MR177_RS04685 1026731..1027819 + 1089 WP_017351234.1 class II fructose-bisphosphatase -
MR177_RS04690 1027850..1029274 + 1425 WP_003405805.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T295276 WP_003405820.1 NZ_OW052570:1024444-1024755 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT295276 WP_003405836.1 NZ_OW052570:1024124-1024444 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References