Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 866174..866733 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag MR177_RS03935 Protein ID WP_003898789.1
Coordinates 866440..866733 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag MR177_RS03930 Protein ID WP_003406322.1
Coordinates 866174..866443 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS03920 861436..862224 + 789 WP_242302854.1 hypothetical protein -
MR177_RS03925 862366..866061 + 3696 WP_015631286.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
MR177_RS03930 866174..866443 + 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR177_RS03935 866440..866733 + 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MR177_RS03940 866790..867620 + 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MR177_RS03945 867701..868561 - 861 WP_003903377.1 glycine betaine ABC transporter substrate-binding protein -
MR177_RS03950 868741..870429 + 1689 WP_003910308.1 PE family protein -
MR177_RS03955 870452..870883 - 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
MR177_RS03960 870880..871140 - 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T295273 WP_003898789.1 NZ_OW052570:866440-866733 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT295273 WP_003406322.1 NZ_OW052570:866174-866443 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References