295272

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 715944..716994 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag MR177_RS03275 Protein ID WP_003407164.1
Coordinates 716173..716994 (-) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID -
Locus tag MR177_RS03270 Protein ID WP_242302848.1
Coordinates 715944..716171 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS03255 711914..713383 - 1470 WP_003900326.1 cytochrome b5 domain-containing protein -
MR177_RS03260 713579..714364 - 786 WP_003407180.1 lipoprotein LprF -
MR177_RS03265 714667..715872 + 1206 WP_003918234.1 serine hydrolase domain-containing protein -
MR177_RS03270 715944..716171 - 228 WP_242302848.1 hypothetical protein Antitoxin
MR177_RS03275 716173..716994 - 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
MR177_RS03280 717215..717601 + 387 WP_003904611.1 anti-sigma-F factor antagonist RsfA -
MR177_RS03285 717740..719701 + 1962 WP_003407159.1 sigma-F factor regulator -
MR177_RS03290 719992..720777 + 786 WP_003407157.1 membrane protein -
MR177_RS03295 720774..721436 + 663 WP_003407152.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T295272 WP_003407164.1 NZ_OW052570:c716994-716173 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8575.63 Da        Isoelectric Point: 8.5691

>AT295272 WP_242302848.1 NZ_OW052570:c716171-715944 [Mycobacterium tuberculosis]
VAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTSEELNVGNGAR

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure

References