Detailed information of TA system TA029527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2083253..2083877
• Replicon: chromosome
• Accession: NC_021485
• Organism: Streptococcus agalactiae 09mas018883

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: BSA_RS10450
• Protein ID: WP_000253103.1
• Coordinates: 2083253..2083600 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: BSA_RS10455
• Protein ID: WP_000543070.1
• Coordinates: 2083590..2083877 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSA_RS10430	2078968..2079324	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
BSA_RS10435	2079391..2081709	-	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
BSA_RS10440	2081848..2082387	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
BSA_RS10445	2082473..2082769	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
BSA_RS10450	2083253..2083600	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSA_RS10455	2083590..2083877	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BSA_RS10460	2083946..2084323	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
BSA_RS11485	2084298..2084450	-	153	Protein_2000	DUF1492 domain-containing protein	-
BSA_RS10465	2084457..2084945	-	489	WP_000891151.1	hypothetical protein	-
BSA_RS10470	2085018..2085575	-	558	WP_001258765.1	hypothetical protein	-
BSA_RS11330	2085733..2085906	-	174	WP_000694573.1	hypothetical protein	-
BSA_RS10480	2085903..2086160	-	258	WP_001069293.1	hypothetical protein	-
BSA_RS10485	2086453..2087847	-	1395	WP_000656430.1	hypothetical protein	-
BSA_RS10490	2087859..2088716	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2082473..2112053	29580

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T29527 WP_000253103.1 NC_021485:c2083600-2083253 [Streptococcus agalactiae 09mas018883]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T29527 NC_021485:c2083600-2083253 [Streptococcus agalactiae 09mas018883]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT29527 WP_000543070.1 NC_021485:c2083877-2083590 [Streptococcus agalactiae 09mas018883]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT29527 NC_021485:c2083877-2083590 [Streptococcus agalactiae 09mas018883]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5