295268

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 317836..318449 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MR177_RS01530 Protein ID WP_003408465.1
Coordinates 318060..318449 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MR177_RS01525 Protein ID WP_003408469.1
Coordinates 317836..318063 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS01505 313728..314438 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
MR177_RS01510 314428..314847 + 420 WP_003408483.1 hypothetical protein -
MR177_RS01515 314890..316137 - 1248 WP_003408476.1 serine hydrolase -
MR177_RS01520 316134..317618 - 1485 WP_003904684.1 biotin carboxylase -
MR177_RS01525 317836..318063 + 228 WP_003408469.1 antitoxin Antitoxin
MR177_RS01530 318060..318449 + 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS01535 318497..318628 - 132 Protein_305 IS3 family transposase -
MR177_RS01545 319059..319838 - 780 WP_003408460.1 IclR family transcriptional regulator -
MR177_RS01550 319852..320670 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
MR177_RS01555 320723..321073 - 351 WP_003898986.1 cupin domain-containing protein -
MR177_RS01560 321073..321903 - 831 Protein_309 cyclase family protein -
MR177_RS01565 321906..322820 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T295268 WP_003408465.1 NZ_OW052570:318060-318449 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT295268 WP_003408469.1 NZ_OW052570:317836-318063 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References