295263

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 26807..27495 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MR177_RS00155 Protein ID WP_003409958.1
Coordinates 27076..27495 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MR177_RS00150 Protein ID WP_003409968.1
Coordinates 26807..27067 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS00125 22298..22897 - 600 WP_003409989.1 L-lysine exporter -
MR177_RS00130 23006..23917 + 912 WP_242302831.1 ArgP/LysG family DNA-binding transcriptional regulator -
MR177_RS00135 24002..24232 - 231 WP_003409980.1 DUF167 domain-containing protein -
MR177_RS00140 24347..25000 + 654 WP_003409976.1 cutinase Cfp21 -
MR177_RS00145 24988..26664 - 1677 WP_003904753.1 PecA family PE domain-processing aspartic protease -
MR177_RS00150 26807..27067 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR177_RS00155 27076..27495 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MR177_RS00160 27720..28688 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MR177_RS00165 28879..29565 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
MR177_RS00170 29744..31189 + 1446 WP_003409946.1 APC family permease -
MR177_RS00175 31152..32000 - 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T295263 WP_003409958.1 NZ_OW052570:27076-27495 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT295263 WP_003409968.1 NZ_OW052570:26807-27067 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References