Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 4421128..4421764 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag MR176_RS20650 Protein ID WP_003410654.1
Coordinates 4421128..4421538 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag MR176_RS20655 Protein ID WP_003410651.1
Coordinates 4421531..4421764 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS20630 4416727..4417950 + 1224 WP_015630218.1 class I SAM-dependent methyltransferase -
MR176_RS20635 4417896..4419422 - 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
MR176_RS20640 4419419..4420043 - 625 Protein_4079 precorrin-8X methylmutase -
MR176_RS20645 4420053..4421144 - 1092 WP_003900454.1 precorrin-3B synthase -
MR176_RS20650 4421128..4421538 - 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
MR176_RS20655 4421531..4421764 - 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
MR176_RS20660 4421842..4425426 + 3585 WP_031651157.1 cobaltochelatase subunit CobN -
MR176_RS20665 4425510..4425914 + 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
MR176_RS20670 4425915..4426307 - 393 WP_229303073.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T295260 WP_003410654.1 NZ_OW052302:c4421538-4421128 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT295260 WP_003410651.1 NZ_OW052302:c4421764-4421531 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References