Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4375079..4375774 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag MR176_RS20445 Protein ID WP_003410811.1
Coordinates 4375340..4375774 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MR176_RS20440 Protein ID WP_003410814.1
Coordinates 4375079..4375333 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS20410 4370429..4370623 + 195 WP_003411026.1 ubiquitin-like protein Pup -
MR176_RS20415 4370620..4371495 + 876 WP_003411023.1 proteasome subunit beta -
MR176_RS20420 4371492..4372238 + 747 WP_003901330.1 proteasome subunit alpha -
MR176_RS20425 4372777..4373508 - 732 WP_003900467.1 PPE family protein -
MR176_RS20430 4373564..4373860 - 297 WP_003410820.1 PE family protein -
MR176_RS20435 4374806..4375063 + 258 WP_003410816.1 hypothetical protein -
MR176_RS20440 4375079..4375333 + 255 WP_003410814.1 antitoxin Antitoxin
MR176_RS20445 4375340..4375774 + 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS20450 4375753..4376586 - 834 WP_003899172.1 SWIM zinc finger family protein -
MR176_RS20455 4376579..4379620 - 3042 WP_003899171.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T295259 WP_003410811.1 NZ_OW052302:4375340-4375774 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT295259 WP_003410814.1 NZ_OW052302:4375079-4375333 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References