Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3942549..3943201 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag MR176_RS18375 Protein ID WP_003412752.1
Coordinates 3942549..3942974 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MR176_RS18380 Protein ID WP_003412749.1
Coordinates 3942980..3943201 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS18350 3937554..3938111 + 558 WP_003412768.1 MaoC family dehydratase -
MR176_RS18355 3938108..3938929 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MR176_RS18360 3939188..3940291 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MR176_RS18365 3940302..3941348 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MR176_RS18370 3941345..3942526 + 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
MR176_RS18375 3942549..3942974 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS18380 3942980..3943201 - 222 WP_003412749.1 antitoxin Antitoxin
MR176_RS18385 3943254..3944006 - 753 WP_003901416.1 hypothetical protein -
MR176_RS18390 3943996..3944619 - 624 WP_003900858.1 TIGR00725 family protein -
MR176_RS18395 3944755..3944961 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T295257 WP_003412752.1 NZ_OW052302:c3942974-3942549 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT295257 WP_003412749.1 NZ_OW052302:c3943201-3942980 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References