Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 3880920..3881557 | Replicon | chromosome |
Accession | NZ_OW052302 | ||
Organism | Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P0DMV7 |
Locus tag | MR176_RS18075 | Protein ID | WP_003413180.1 |
Coordinates | 3881162..3881557 (+) | Length | 132 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ44 |
Locus tag | MR176_RS18070 | Protein ID | WP_003413183.1 |
Coordinates | 3880920..3881165 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MR176_RS18050 | 3877514..3878026 | + | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
MR176_RS18055 | 3878019..3879272 | + | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
MR176_RS18060 | 3879269..3880078 | + | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
MR176_RS18065 | 3880090..3880509 | + | 420 | WP_003413190.1 | A24 family peptidase | - |
MR176_RS18070 | 3880920..3881165 | + | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | Antitoxin |
MR176_RS18075 | 3881162..3881557 | + | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | Toxin |
MR176_RS18080 | 3881657..3882031 | + | 375 | WP_003413177.1 | hypothetical protein | - |
MR176_RS18085 | 3882047..3882424 | - | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
MR176_RS18090 | 3882421..3882678 | - | 258 | WP_003413167.1 | CopG family transcriptional regulator | - |
MR176_RS18095 | 3882717..3883130 | - | 414 | WP_003413164.1 | PIN domain nuclease | - |
MR176_RS18100 | 3883223..3883501 | - | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
MR176_RS18105 | 3883498..3884160 | - | 663 | WP_023643170.1 | LppA family lipoprotein | - |
MR176_RS18110 | 3884157..3884816 | - | 660 | WP_003900846.1 | LppA family lipoprotein | - |
MR176_RS18115 | 3884943..3886154 | - | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14619.53 Da Isoelectric Point: 6.9794
>T295253 WP_003413180.1 NZ_OW052302:3881162-3881557 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
Download Length: 396 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 5WZ4 | |
PDB | 5WZF |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BW31 |