Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 239302..239914 Replicon chromosome
Accession NC_021485
Organism Streptococcus agalactiae 09mas018883

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag BSA_RS01385 Protein ID WP_000384858.1
Coordinates 239302..239637 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag BSA_RS01390 Protein ID WP_000255538.1
Coordinates 239627..239914 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSA_RS01360 234489..235118 + 630 WP_000591148.1 hypothetical protein -
BSA_RS01365 235442..236317 + 876 WP_000770113.1 hypothetical protein -
BSA_RS01370 236353..236787 + 435 WP_001220479.1 hypothetical protein -
BSA_RS01375 237103..238359 + 1257 WP_000122832.1 plasmid recombination protein -
BSA_RS01380 238527..238997 + 471 WP_000130119.1 hypothetical protein -
BSA_RS01385 239302..239637 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSA_RS01390 239627..239914 - 288 WP_000255538.1 hypothetical protein Antitoxin
BSA_RS01395 240317..241537 - 1221 WP_000156558.1 tyrosine-type recombinase/integrase -
BSA_RS01400 241598..241858 - 261 WP_001196072.1 helix-turn-helix domain-containing protein -
BSA_RS01405 241870..242616 - 747 WP_000966632.1 hypothetical protein -
BSA_RS01410 242802..243593 - 792 WP_001868842.1 hypothetical protein -
BSA_RS01415 243574..244107 - 534 WP_000680721.1 hypothetical protein -
BSA_RS01420 244107..244445 - 339 WP_001187920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 191073..241642 50569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T29525 WP_000384858.1 NC_021485:c239637-239302 [Streptococcus agalactiae 09mas018883]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T29525 NC_021485:c239637-239302 [Streptococcus agalactiae 09mas018883]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT29525 WP_000255538.1 NC_021485:c239914-239627 [Streptococcus agalactiae 09mas018883]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT29525 NC_021485:c239914-239627 [Streptococcus agalactiae 09mas018883]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References