Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
Location | 239302..239914 | Replicon | chromosome |
Accession | NC_021485 | ||
Organism | Streptococcus agalactiae 09mas018883 |
Toxin (Protein)
Gene name | parE | Uniprot ID | Q8E1X3 |
Locus tag | BSA_RS01385 | Protein ID | WP_000384858.1 |
Coordinates | 239302..239637 (-) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | Q8E1X2 |
Locus tag | BSA_RS01390 | Protein ID | WP_000255538.1 |
Coordinates | 239627..239914 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BSA_RS01360 | 234489..235118 | + | 630 | WP_000591148.1 | hypothetical protein | - |
BSA_RS01365 | 235442..236317 | + | 876 | WP_000770113.1 | hypothetical protein | - |
BSA_RS01370 | 236353..236787 | + | 435 | WP_001220479.1 | hypothetical protein | - |
BSA_RS01375 | 237103..238359 | + | 1257 | WP_000122832.1 | plasmid recombination protein | - |
BSA_RS01380 | 238527..238997 | + | 471 | WP_000130119.1 | hypothetical protein | - |
BSA_RS01385 | 239302..239637 | - | 336 | WP_000384858.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BSA_RS01390 | 239627..239914 | - | 288 | WP_000255538.1 | hypothetical protein | Antitoxin |
BSA_RS01395 | 240317..241537 | - | 1221 | WP_000156558.1 | tyrosine-type recombinase/integrase | - |
BSA_RS01400 | 241598..241858 | - | 261 | WP_001196072.1 | helix-turn-helix domain-containing protein | - |
BSA_RS01405 | 241870..242616 | - | 747 | WP_000966632.1 | hypothetical protein | - |
BSA_RS01410 | 242802..243593 | - | 792 | WP_001868842.1 | hypothetical protein | - |
BSA_RS01415 | 243574..244107 | - | 534 | WP_000680721.1 | hypothetical protein | - |
BSA_RS01420 | 244107..244445 | - | 339 | WP_001187920.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 191073..241642 | 50569 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 13264.04 Da Isoelectric Point: 5.2388
>T29525 WP_000384858.1 NC_021485:c239637-239302 [Streptococcus agalactiae 09mas018883]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK
Download Length: 336 bp
>T29525 NC_021485:c239637-239302 [Streptococcus agalactiae 09mas018883]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10921.47 Da Isoelectric Point: 4.7271
>AT29525 WP_000255538.1 NC_021485:c239914-239627 [Streptococcus agalactiae 09mas018883]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL
Download Length: 288 bp
>AT29525 NC_021485:c239914-239627 [Streptococcus agalactiae 09mas018883]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1EF10 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1EFF9 |