Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3573466..3574014 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag MR176_RS16400 Protein ID WP_003414602.1
Coordinates 3573466..3573729 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag MR176_RS16405 Protein ID WP_003414599.1
Coordinates 3573733..3574014 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS16380 3568540..3569781 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MR176_RS16385 3569789..3571003 + 1215 WP_003414610.1 zinc metalloprotease Rip -
MR176_RS16390 3571020..3572183 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MR176_RS16395 3572239..3573093 + 855 WP_003899516.1 GNAT family N-acetyltransferase -
MR176_RS16400 3573466..3573729 - 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MR176_RS16405 3573733..3574014 - 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
MR176_RS16410 3574286..3576097 + 1812 WP_003414596.1 penicillin-binding protein -
MR176_RS16415 3576179..3576559 - 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
MR176_RS16420 3576556..3576804 - 249 WP_003913411.1 antitoxin VapB23 -
MR176_RS16425 3576908..3577492 + 585 WP_003414585.1 DUF1707 domain-containing protein -
MR176_RS16430 3577534..3578391 + 858 WP_016719566.1 type I methionyl aminopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T295245 WP_003414602.1 NZ_OW052302:c3573729-3573466 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT295245 WP_003414599.1 NZ_OW052302:c3574014-3573733 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References