Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3567726..3568413 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag MR176_RS16370 Protein ID WP_003414624.1
Coordinates 3567726..3568169 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag MR176_RS16375 Protein ID WP_003414620.1
Coordinates 3568156..3568413 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS16345 3563574..3563840 - 267 WP_015456449.1 DUF2631 domain-containing protein -
MR176_RS16350 3563940..3564521 - 582 WP_003414644.1 fasciclin domain-containing protein -
MR176_RS16355 3564617..3566365 - 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
MR176_RS16360 3566697..3566888 - 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MR176_RS16365 3566984..3567646 - 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
MR176_RS16370 3567726..3568169 - 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS16375 3568156..3568413 - 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
MR176_RS16380 3568540..3569781 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MR176_RS16385 3569789..3571003 + 1215 WP_003414610.1 zinc metalloprotease Rip -
MR176_RS16390 3571020..3572183 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MR176_RS16395 3572239..3573093 + 855 WP_003899516.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T295244 WP_003414624.1 NZ_OW052302:c3568169-3567726 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT295244 WP_003414620.1 NZ_OW052302:c3568413-3568156 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References